The Crystal Palace forward, who was named Man of the Match in the defeat on Saturday left Selhurst Park in tears after what seems like a hamstring injury.
It is yet to be determined the extent of his injury but the Ghana Football Association will be waiting on a scan from the Palace medics to decide on his AFCON participation.
“I don’t know, I haven’t spoken to the doctor yet,” said manager Patrick Vieira in relation to Ayew’s injury.
Although he played the entire game, the 30-year-old attacker was in discomfort after the match.
Should he be declared unfit, that will be a huge blow for Ghana coach Milovan Rajevac.